Human C Reactive (Active)

Human C-Reactive Protein (CRP) is a pentameric acute-phase reactant of the pentraxin family, produced by hepatocytes in response to inflammatory cytokines such as IL-6. The unconjugated active protein from Antibodies.com is delivered as a 1 mg liquid preparation, serving as a reference standard or calibrator in ELISA, western blot, and biochemical studies of complement activation pathways.

The native pentamer carries a molecular weight of approximately 115 kDa and binds phosphorylcholine residues on microbial surfaces and damaged cell membranes, activating the classical complement cascade via C1q. Investigators working on cardiovascular risk stratification, sepsis biomarkers, autoimmune disease activity, and post-surgical inflammatory monitoring use purified CRP in receptor binding experiments and cell culture stimulation assays.

Aliquot upon receipt and store frozen at -80 degrees C; avoid repeated freeze-thaw cycles to preserve pentameric integrity. The unconjugated format permits direct biotinylation or fluorescent labeling for custom assay development. For research use only.