Ceruloplasmin Antigen ≥95%

Highly purified ceruloplasmin antigen supplied as a 2 mg lyophilized vial by Antibodies.com, formulated in 50 mM potassium phosphate buffer at pH 6.8 with 150 mM KCl, 20 mM ε-amino caproic acid as a protease inhibitor, and 5 mM EDTA. The ≥95% purity level makes this preparation useful as an immunogen for antibody generation, a coating reagent in immunoassay development, or a reference standard in ELISA and western blot workflows. Ceruloplasmin is a blue, copper-binding glycoprotein synthesized primarily by hepatocytes that transports the majority of circulating plasma copper and functions as a ferroxidase, oxidizing Fe²⁺ to Fe³⁺ for loading onto transferrin. Researchers investigating iron homeostasis, acute-phase inflammation, and copper metabolism rely on well-characterized antigen preparations to validate antibody binding, calibrate clinical assays, or spike samples for recovery experiments. The lyophilized format provides extended shelf stability when kept sealed and dry; reconstituted material should be aliquoted and frozen to preserve activity across multiple freeze-thaw cycles. This reagent serves as a valuable control in studies of Wilson disease and aceruloplasminemia, where ceruloplasmin levels or copper-transport activity are disrupted, and supports immunohistochemistry, immunoprecipitation, and affinity-purification applications.