Adenovirus Type 1, Canine Antigen

Antigens derived from canine adenovirus type 1 (CAV-1) supply the biological target used to detect antibodies or viral particles in veterinary diagnostics. This liquid-form preparation from Antibodies.com is supplied at a 1 mg packaging size and serves as a coating reagent in plate-based immunoassays.

CAV-1 is the etiologic agent of infectious canine hepatitis, a contagious disease of dogs characterized by hepatic and renal involvement. Reliable in vitro detection of CAV-1 exposure supports vaccination monitoring, herd screening in kennels and breeding operations, and differential diagnosis from other causes of canine liver disease.

Laboratory applications include:

• Coating microplates for indirect immunoassays to measure anti-CAV-1 antibodies in canine serum
• Use as a positive control antigen in western blot confirmation protocols
• Incorporation in reference panels for assay validation of veterinary diagnostic kits
• Immunohistochemistry on fixed tissue sections from infected animals

Cross-reactivity note: CAV-1 and canine adenovirus type 2 (CAV-2) share hexon epitopes, so polyclonal antibodies raised against this antigen may also recognize CAV-2 isolates. Researchers targeting CAV-1 specifically should confirm specificity using type-specific monoclonal antibodies or PCR.

Storage and handling recommendations: divide into single-use aliquots upon receipt to limit freeze-thaw cycles; store frozen at -80 °C for long-term preservation. Protect from light and avoid repeated freeze-thaw events, which can denature native viral epitopes and reduce binding activity in downstream assays. Intended for research use only.