Human Interleukin-22 ELISA Kit

Researchers investigating mucosal immunity, chronic inflammatory disease, and epithelial repair can use the Antibodies.com Human Interleukin-22 ELISA Kit to quantify IL-22, a cytokine of the IL-10 family that signals through the IL-22R1/IL-10R2 receptor complex on epithelial and stromal cells. The kit supports immunology, dermatology, and gastroenterology studies where IL-22 is a key biomarker, including work on psoriasis, inflammatory bowel disease, viral hepatitis, and chronic obstructive pulmonary disease.

Packaged in a three-plate format totaling 576 wells, the layout suits medium-to-high throughput study designs. IL-22 is produced by Th17 and Th22 lymphocytes and innate lymphoid cells, where it drives keratinocyte hyperproliferation in psoriatic skin lesions while promoting barrier restoration in the gut and airway after injury or infection.

Samples commonly prepared for this assay include cell culture supernatant, tissue homogenate, and matched biofluid samples from clinical cohorts. Standard practice is to aliquot reconstituted standards into single-use vials and store them frozen to limit freeze-thaw cycles, while sealed kit components are kept refrigerated and protected from light. Researchers often pair ELISA-based IL-22 quantification with immunohistochemistry on biopsy sections to link circulating or local cytokine levels with specific cellular sources within affected tissue.