Cancer Antigen 125 (CA 125) Antigen

MUC16, also known as CA 125 or Cancer Antigen 125, is a heavily glycosylated transmembrane mucin protein recognized as a clinically established serum tumor marker, most prominently used in monitoring epithelial ovarian carcinoma and evaluating pelvic masses. The antigen carries numerous tandem repeat epitopes that are recognized by the OC125-class monoclonal antibodies widely used in clinical immunoassays.

Antibodies.com supplies this Cancer Antigen 125 (CA 125) Antigen as a liquid preparation of 10 kU activity, supporting immunoassay development, antibody generation, and analytical method validation workflows. Researchers employ this reagent as a calibrator or reference standard when quantifying CA 125 in patient samples, and it can be coated onto plates to evaluate antibody binding kinetics or used as an immunogen to raise specific polyclonal or monoclonal reagents. Each unit corresponds to a defined antigen activity value, allowing direct conversion into concentration ranges for assay setup.

For best stability, store the liquid antigen frozen at -20 degrees C in working aliquots to limit freeze-thaw cycles, and thaw on ice immediately before use. Brief handling on wet ice and prompt return to freezer preserves epitope integrity between experimental sessions. This reagent is for research use only and is not approved for diagnostic procedures.