Amphotericin B

Amphotericin B — Amphotericin B is a broad-spectrum polyene antifungal used for severe systemic fungal infections. It exerts fungicidal or fungistatic effects by binding to ergosterol in fungal cell membranes and forming transmembrane pores that increase membrane permeability and lead to cell death. Source

Indications: Typically reserved for progressive or life-threatening invasive mycoses (e.g., invasive candidiasis, cryptococcal meningitis, mucormycosis, and severe aspergillosis) where potent, rapid antifungal activity is required. Source

Product Information: Supplied as a 250 mg size (lyophilized powder for reconstitution and intravenous infusion). Multiple formulations exist (deoxycholate and lipid/liposomal forms) with different tolerability and renal toxicity profiles; choose based on clinical context. Manufacturer: MOLEQULE-ON, New Zealand. Supplier: EMDA. Source

Key Features: Broad antifungal activity against a wide range of systemic pathogens; lipid/liposomal formulations reduce infusion-related and renal toxicity compared with conventional deoxycholate preparations; suitable for critically ill or immunocompromised patients needing definitive therapy. Source

Safety and Monitoring: Associated with infusion-related reactions (fever, rigors) and dose-dependent nephrotoxicity plus electrolyte disturbances (hypokalemia, hypomagnesemia). Monitor renal function and serum electrolytes during therapy; consider slow infusion and premedication to reduce acute reactions. Source

Storage and Handling: For hospital use only; reconstitute and administer by intravenous infusion under clinical supervision with appropriate monitoring and supportive care. Refer to product labeling and local protocols for dosing and administration details.