WNT Inhibitor (IWP-2) Cas # 686770-61-6

WNT Inhibitor (IWP-2) Cas # 686770-61-6

WNT Inhibitor (IWP-2) Cas # 686770-61-6 — enhanced description: A research-grade small-molecule inhibitor of Wnt production that inactivates Porcupine (Porcn)-mediated palmitoylation of Wnt proteins and reduces downstream β-catenin signaling. This product is supplied as a crystalline solid intended for in vitro research use only; not for human or clinical applications.

([biomol.com](https://www.biomol.com/products/chemicals/biochemicals/iwp-2-cay13951-1?utm_source=openai))

Manufacturer: MOLEQULE-ON, New Zealand.

Key features:

• Selective inhibition of Porcn-dependent Wnt secretion (cell-free IC50 ≈ 27 nM).
• Demonstrated activity in cell-based assays at low micromolar concentrations (commonly used 0.5–5 μM depending on assay).
• Useful in Wnt pathway research, stem cell differentiation protocols, and preclinical cancer biology studies to modulate Wnt-driven phenotypes.

([selleckchem.com](https://www.selleckchem.com/products/iwp-2-wnt-pathway-inhibitor.html?utm_source=openai))

Specifications (typical):
Form: crystalline solid; Size: 50 mg; Molecular formula: C22H18N4O2S3; Molecular weight: 466.6 g·mol⁻¹; Typical purity >95% (batch-dependent).

([biomol.com](https://www.biomol.com/products/chemicals/biochemicals/iwp-2-cay13951-1?utm_source=openai))

Handling & storage: Store powder at -20°C (stable for years when dry). Prepare stock solutions in anhydrous DMSO (e.g., 20 mg/mL) and store aliquots at -80°C; avoid moisture and repeated freeze–thaw. Work at recommended concentrations and include appropriate vehicle controls.

([selleckchem.com](https://www.selleckchem.com/wnt-pathway-inhibitor/iwp-2.html?utm_source=openai))

Common applications & notes: Use for probing Wnt signaling (mechanistic studies, reporter assays, target validation), directing pluripotent stem cell differentiation by transient Wnt suppression, and in vitro cancer cell proliferation/migration assays. Optimize dose and exposure for each cell line; include pathway readouts (β-catenin, LRP6 phosphorylation, Axin2) to confirm on-target effects.

([invivochem.com](https://www.invivochem.com/iwp-2.html?utm_source=openai))

Note: Product description enhances the supplied information and is intended to guide research use. Consult batch COA and safety data sheet for lot-specific purity, storage, and safety details prior to use.